Chennai, Feb 28 : The Indian Institute of Technology, Madras, (IIT-M) and Sankara Nethralaya researchers have modelled the biochemical principles of Retinoblastoma and identified pathways by which diseased cells obtain energy for survival and proliferation in a cross-departmental study.
This Research led to identifying five more new drug targets, which offer the potential for developing new and more effective drugs with minimal side-effects. The published work was the first study to use Constraint-Based Modeling (CBM) to predict metabolic biomarkers for diagnosis of Retinoblastoma in Indian patients and to suggest novel drug targets for its treatment.
An IIT-M release on Thursday said their work has recently been published in the Journal FEBS Letters, a platform for the four journals owned by the not-for-profit Federation of European Biochemical Societies (FEBS).
Leading medical and genomics research organizations in India and the US contributed to this research, it said. Retinoblastoma was a rare form of cancer that affects one in every 1,500 children across the world.
In India alone, 1,500 new cases of Paediatric Retinoblastoma were reported every day, adding tremendously to the socio-economic burden of cancer care. Stating that the most common symptoms of this disease were the appearance of a white dot in the retina and squint, the release said as with most forms of cancer, the key to retinoblastoma management was early detection and treatment.
The Research Team comprised Dr Swagatika Sahoo, DST-INSPIRE Faculty, Department of Chemical Engineering, and Initiative for Biological Systems Engineering (IBSE), IIT Madras, Dr Sailaja V. Elchuri, Associate Professor, Department of Nanotechnology, Vision Research Foundation, Sankara Nethralaya, Dr Karthik Raman, Associate Professor, Department of Biotechnology and Coordinator, IBSE, IIT Madras, besides Mr Ranjith Kumar Ravi Kumar, Masters Student, Department of Nanotechnology, Vision Research Foundation, Sankara Nethralaya. UNI